Archive 2020

Release of the Full and Short FAD – Mu.Ta.Lig COST Action CA15135 Video produced by Net4Science

Net4Science is proud to announce the release of the Full and Short versions of the Final Action Dissemination (FAD) – Mu.Ta.Lig COST Action CA15135 Video, which are now available at the www.mutalig.eu.

The Mu.Ta.Lig COST Action started on April 2016 with the aim to join several highly-qualified research teams to improve the multi-target drug discovery. It has been active for four years and more than 30 European countries have been involved in this project. Net4Science started to strongly collaborate with the Mu.Ta.Lig COST Action for scientific and dissemination projects. Indeed, most of the Net4Science publications were made in collaboration with this COST Action. Additionally, another effective project carried out by the Net4Science spinoff was the recent release of three Chemotheca video tutorials, created with the aim to support the use of the Chemotheca tool.

Last October it was planned the idea to complete the dissemination program through the collection of all the documentation related to the meetings, scientific publications, mobility and interviews, which gave birth to the Final Action Dissemination (FAD).

Both of the FAD versions highlight the four-year journey of the Mu.Ta.Lig COST Action CA15135 as well as the main outputs achieved, including publications on peer-reviewed articles, scientific contributions held during the Annual Meetings, the Working Group (WG) Meetings and the Training Schools. Further documentation and the goals achieved are also exposed through the WG leader’s interview.

Unfortunately, the COVID emergency created some problems and has delayed the production of the planned FAD multimedia product, but it didn’t prevent the release exactly on the day expected (April 21st 2020).

Both the two YouTube versions of the FAD video are accessible through the official website www.mutalig.eu or directly to the following links:

Short version (about 4 min)

Full video  (about 18 min)

The capacity of the Net4Science spinoff to valorize the consistent scientific efforts done in this four-year extraordinary journey is demonstrated in this multimedia product and can be considered an added value of this innovative SME.

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Net4Science is fully involved in the ENTRAP-Cov IMI2 call 21 EU proposal against the SARS-CoV-2 virus

The Innovative Medicines Initiative (IMI) is the Europe’s largest public-private partnership in the Life Sciences. Its aim is to speed up the development of better and safer medicines for patients, particularly in areas where there is an unmet medical or social need. IMI facilitates collaboration among universities, research centers, pharmaceutical and other industries, small and medium-sized enterprises (SMEs), patient organizations, and medicines regulators. Through the IMI2 programme, the budget for the period 2014-2020 is €3.3 billion. Since the SARS-CoV-2 outbreak exploded, also IMI has promptly made significant resources available on the IMI2 Call 21 in order to provide novel diagnostic and therapeutic tools against SARS-CoV-2 virus. Several research groups have worked to apply credible and potentially fundable proposals.

At the University “Magna Græcia” of Catanzaro, the Medicinal Chemistry group, by means of the academic spinoff Net4Science, in collaboration with the Infectivology group of the Department of Medical and Surgery Sciences, have been involved in a new consortium consisting of more than 25 partners dedicated to dealing with the coronavirus emergency with all the available scientific resources.
The project leader is the Virology team of the University of Rome “Tor Vergata”, through the scientific proposal entitled “Evolutionary Novel Approaches for a Therapeutic Response Against Pan Coronaviruses (ENTRAP-Covs)” submitted to the IMI2 Call 21 “Development of therapeutics and diagnostics combatting coronavirus infections”. The proposal puts together prominent Italian partners and others located in various parts of Europe (France, Belgium, Germany, Holland, Hungary, United Kingdom). The network includes universities (Rome Tor Vergata, Catanzaro, Milan, Palermo, Rega Institute KU Leuven, Hamburg, Hannover, Liverpool), institutions and foundations (Istituto Nazionale Malattie Infettive “Lazzaro Spallanzani”, Ospedale Pediatrico Bambino Gesù of Rome, INSERM of Paris, Fondazione Aviralia, Telethon), SMEs and big pharma companies (Net4Science srl academic spinoff, Chemical and Pharmaceutical Innovation TANK, Pharmacoidea Ltd, Good Clinical Practice Alliance – Europe, Artemis Bio-Support, MiDiagnostics, First Health Pharmaceuticals, Takis, Menarini Ricerche, Menarini Biotech, Zambon, Astra Zeneca, Merck Sharp & Dohme, Diasorin).

The ENTRAP-Covs consortium aims at the following objectives:
1. Repurposing and drug discovery against SARS-CoV-2.
2. Fast early diagnostics.
3. Biomarker identification by analyzing both viral and host factors responsible for SARS-CoV-2 pathogenesis.

The partner networking, articulated through specific work packages, will be able to provide innovative diagnostic and therapeutic tools to fight the SARS-CoV-2 outbreak, will contribute to the internationalization levels of the University’s research in Europe and will consolidate the performances and competitiveness of the involved companies.

The project was submitted on March 31st 2020 and is currently under evaluation.

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Net4Science has submitted its first patent request for innovative multi-target anticancer agents

Technological transfer is one of the major issues of the young academic spinoff Net4Science. During its first year of activity, a consistent work was carried out by our scientists with the aim to develop novel multi-target small molecules against neoplastic diseases. A family of novel heterocycle compounds, were characterized and tested on preliminary models of hematological cancers. The inhibition properties and the multiple mechanism of action profile them as promising therapeutic tools, especially against lymphoma and leukemia.

Net4Science provided also with full application of this invention directly submitting it a European level. It includes the synthetic procedure to prepare the proposed series of novel inhibitors, their full chemical characterization, in vitro early toxicity and off-target liability assays, best candidate IC50 values for a set of them against six lymphoma cell lines.

The patent has been submitted on January 2020 and in few months will be available. Any request about it can be done contacting us by email or phone.

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Net4Science is fully involved in the PTRAIN Marie Skłodowska-Curie EU proposal

PTRAIN is the acronym of “Polypharmacology TRAIning Network”, a Marie Skłodowska-Curie Action dedicated to the first top-level training to a pool of talented ESRs working in the innovative and interdisciplinary field of polypharmacology. Its scope is to integrate various computational approaches with experimental medicinal chemistry within a superb collaborative European setting.

PTRAIN is organized into scientific six Work Packages (WPs). The first three WPs are mainly focusing on specific issues where the potential beneficiary Net4Science is able to give a consistent support, such as polypharmacology-based drug design and discovery, ligand-based and structure-based drug design, data-driven and statistical approaches, big data analysis, machine learning and artificial intelligence,
chemoinformatics, structural bioinformatics and network biology, big data analysis and database generation. The other three WPs are, instead, dedicated to Training, Dissemination and Management.

The network includes scientific leaders from nine top-ranking universities, three research centers, one International Organization of  uropean Interest and six internationally-recognized companies based on seven different EU countries, thus indicating the excellence of the project.

All the participants are world-renowned scientists actively involved in research and teaching, bringing in the network a variety of backgrounds and expertise and providing an excellent foundation for multi-disciplinary training. PTRAIN’s fellows will be exposed to both computational/experimental as well as academic/industrial settings, thus strengthening their training and capacity.
Participation to six schools and practical hands-on courses, e-lectures, secondments and work on common research topics, will warrant a unique training opportunity.

The project was submitted on January 14 th 2020 and is currently under evaluation.

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Net4Science – First Year Activity Report (Year 2019)

During the first year of its existence,  the Net4Science academic spinoff  has focused its activity to grow its business in the marketplace panorama  by looking for direct collaborations with both regional, national and foreign companies and institutions. Such activity aims both to enhance the academic scientific research and to share its scientific skills with the production system through both the creation and the support of innovative and technologically advanced projects.

It has been an intense year full of commitments and with many satisfactions that have allowed the whole Net4Science team to accumulate a considerable experience and to increase their skills in several important fields.

The first relevant initiatives were launched just few months before Net4Science was set up. In October 2018, in fact, Net4Science was invited by the University “Magna Græcia” of Catanzaro to take part at the “Maker Faire” innovation event  in Rome (link) and, similarly, CalabriaInnova has chosen Net4Science to participate at the technology and innovation fair SMAU in Milan (link), as part of Phase 1 of the Start-up and Spin-off call of the Calabria Region (link), which was an opportunity  to interact with the business world in relation to the many applications of scientific research.

The formal establishment of Net4Science s.r.l took place on December 18th 2018 and at the same time the spinoff was included in the special register of innovative startups of the Chamber of Commerce of Catanzaro.

Then, during the first half of 2019, the Net4Science team was constantly involved in the completion of the Phase 2 of the above mentioned Start-up and Spin-off call of the Calabria Region call for proposals, which ended with the approval of European funding for the implementation of our business development plan (link).

During the first part of this period, Net4Science was involved, on behalf of COST (European Cooperation in Science and Technology), in the dissemination of scientific results related to the COST Action MuTaLig (Multi-target paradigm for innovative ligand identification in the drug discovery process), taking care of the website www.mutalig.eu and producing the Chemotheca video tutorials (link).

Subsequently, from June 13th-15th 2019, Net4Science organized the international conference MedChem2019 – Paul Ehrlich Euro-PhD Network & MuTaLig COST Action meeting, which was held at the prestigious Complesso Monumentale San Giovanni of  and was attended by saw the presence of about 150 participants from 20 European countries, including high-level university professors and young researchers and companies with an outstanding role in the field of medicinal chemistry (link).

In October 2019 Net4Science participated at the information event of the Golinelli Foundation of Bologna on “Call Life Science 2020” to learn more about this important opportunity that supports  scientific research through the training, the dissemination and funding of innovative projects (link).

Between October and November 2019, Net4Science has participated to the SPIN – Scaleup Program Invitalia Network, promoted by the Italian Ministry of Economic Development and dedicated to the business development of SMEs, innovative startup and university spinoff. Net4Science has been selected among the 70 companies that will be able to take advantage of the services of ELITE, a London Stock Exchange group company, which supports companies and guides following a process that brings them closer to capital markets and the world of open innovation (link).

Net4Science has concluded its first year of activity organizing the the Workshop entitled “Scientific Research and Enterprise Enhancement” – From agrifood to nutraceutical: competitive itineraries for the development of the territory, in which many companies belonging to the agricultural field took part and in which topics concerning the opportunities for the valorization of typical products and the use of public and private financial instruments for the economic support of business development projects were discussed (link).

Along with the above-mentioned actions, a consistent work in the field of the scientific research was carried out daily by the whole Net4Science team with tireless constancy, which constitutes the fundamental pillar of offered services. A very important investment in knowledge for the spinoff, translated in the first year alone into fourteen scientific publications on peer-reviewed journals that represent the current scientific portfolio of Net4Science (link).

After these first steps, not easy but full of satisfactions, Net4Science intends to follow the path taken with conviction and tenacity, setting itself the goal of making available to pharmaceutical companies and agrifood the knowledge accumulated over the years in the laboratories of the Medicinal Chemistry Group of the University “Magna Græcia” of Catanzaro.

 

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