The international cooperation in scientific research is a key point of success. Recently on European Journal of Medicinal Chemistry (Elsevier edition) a special issue on multi-target drug discovery (MTDD) was launched. The COST rules allow to support the open access version contribution if three or more different countries are involved in the publication. Among the currently accepted manuscripts one fulfilled all items within the third grant period of the MuTaLig COST Action. The topic is related to the design and development of MTDD compounds able to exert beneficial affect against neurodegenerations, and especially Alzheimer disease. The work is carried out by the collaboration of Portuguese, Spanish and Italian teams, including components of the Net4Science academic spinoff. The manuscript is freely accessible at this link https://doi.org/10.1016/j.ejmech.2019.04.026.