Poly-pharmacology: the rise of multi-target drugs

Multi-target drugs have aroused considerable interest in the last decade, both in academia and in companies, thanks to their advantages in the treatment of complex diseases and health conditions also related to the resistance matters. The repurposing issue of compounds for the
treatment of complex diseases is a further application of multi-target ligands. Net4Science is active in the poly-pharmacology and multi-target drug discovery with specific services for pharmaceutical and nutraceutical institutions working at national and international level. To date, the one-drug-one-target concept is evolving towards from the traditional view “lock and key” model to “one-drug multiple-targets”. In fact, pharmacological effects, often due to the interaction of single drugs with multiple targets, are encouraging to shift the scientific investigations toward experimental and computational multi-target approaches.